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Conolidine’s analgesic results stem from its interaction with non-opioid pain pathways. Contrary to opioids, which bind to µ-opioid receptors in the central nervous program, conolidine modulates alternate molecular targets. A Science Innovations research found that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regu

Transcutaneous electrical nerve stimulation (TENS) can be a surface area-applied device that provides very low voltage electrical present-day in the pores and skin to generate analgesia.Provided the system of action of conolidine unlike opioids which in turn would do respiratory harm. It wouldn't cause a lethal overdose the way opioids would.Cellp